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ionizable lipids sm 102  (Cayman Chemical)


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    Cayman Chemical ionizable lipids sm 102
    Ionizable Lipids Sm 102, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 96/100, based on 61 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ionizable+lipids+sm+102/SM-102/pm41798954-68-1-5
    Average 96 stars, based on 61 article reviews
    ionizable lipids sm 102 - by Bioz Stars, 2026-10
    96/100 stars

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    Related Articles

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    Article Title: mRNA-based SARS-CoV-2 vaccines: intracellular processing and aggregation of the encoded spike protein as a mechanistic contributor to cardiac cellular stress.
    Article Snippet: Lipid nanoparticle formulation and characterization Lipid nanoparticles were produced by microfluidic mixing using the NanoAssemblr Spark platform (Cytiva, USA). .. The ionizable lipids SM-102 (#Cay33474, Cayman Chemical, USA) and ALC-0315 (#890900), the phospholipid 1,2-distearoyl-snglycero-3-phosphocholine (DSPC, #850365), the pegylated lipids 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (DMG-PEG2000, #880151) or ALC-0159 (#880155) and cholesterol (#700100) (Avanti Polar Lipids Inc., USA) were dissolved in ethanol at a total lipid concentration of 40 mM. .. To characterize the protein complexes formed post-translationally, AC16 cardiomyocytes were pre-incubated with furin inhibitor I (final concentration: 20 μM; #344930, Merck KGaA, Germany) for 1 hour prior to the application of BNT162b2 or mRNA-1273.

    Article Title: mRNA-based SARS-CoV-2 vaccines: intracellular processing and aggregation of the encoded spike protein as a mechanistic contributor to cardiac cellular stress
    Article Snippet: Lipid nanoparticles were produced by microfluidic mixing using the NanoAssemblr Spark platform (Cytiva, USA). .. The ionizable lipids SM-102 (#Cay33474, Cayman Chemical, USA) and ALC-0315 (#890900), the phospholipid 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC, #850365), the pegylated lipids 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 (DMG-PEG2000, #880151) or ALC-0159 (#880155) and cholesterol (#700100) (Avanti Polar Lipids Inc., USA) were dissolved in ethanol at a total lipid concentration of 40 mM. ..



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    Effect of buffer species of 50 mM acidic buffer used to <t>form</t> <t>SM-102</t> FLuc LNPs on liquid stability and bleb formation. (a) Percentage of bleb formation of LNPs obtained from cryo-TEM images. (b) Ratio of luminescence of HeLa cells transfected with LNPs before and after storage for 3 weeks at 25°C (%activity remaining). (c) Representative cryo-TEM images of LNPs before storage at 25°C. Scale bars represent 200 nm. Data are presented as mean ± SD (ANOVA with post-hoc Tukey’s multiple comparison test, n = 3). * P < 0.05.
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    Image Search Results


    Effect of buffer species of 50 mM acidic buffer used to form SM-102 FLuc LNPs on liquid stability and bleb formation. (a) Percentage of bleb formation of LNPs obtained from cryo-TEM images. (b) Ratio of luminescence of HeLa cells transfected with LNPs before and after storage for 3 weeks at 25°C (%activity remaining). (c) Representative cryo-TEM images of LNPs before storage at 25°C. Scale bars represent 200 nm. Data are presented as mean ± SD (ANOVA with post-hoc Tukey’s multiple comparison test, n = 3). * P < 0.05.

    Journal: bioRxiv

    Article Title: Bleb formation induced by acidic mixing buffers improves liquid stability of mRNA-LNPs

    doi: 10.64898/2026.03.05.709631

    Figure Lengend Snippet: Effect of buffer species of 50 mM acidic buffer used to form SM-102 FLuc LNPs on liquid stability and bleb formation. (a) Percentage of bleb formation of LNPs obtained from cryo-TEM images. (b) Ratio of luminescence of HeLa cells transfected with LNPs before and after storage for 3 weeks at 25°C (%activity remaining). (c) Representative cryo-TEM images of LNPs before storage at 25°C. Scale bars represent 200 nm. Data are presented as mean ± SD (ANOVA with post-hoc Tukey’s multiple comparison test, n = 3). * P < 0.05.

    Article Snippet: Specifically, we investigated the effect of less common acidic buffers on mRNA-LNP stability using a LNP containing a clinically relevant ionizable lipid (SM-102) that is used by Moderna as a part of their respiratory vaccine platform LNP.

    Techniques: Transfection, Activity Assay, Comparison

    Effect of apparent ionic strength of 50 mM pH 4 acidic mixing buffers on bleb formation of SM-102 LNPs.

    Journal: bioRxiv

    Article Title: Bleb formation induced by acidic mixing buffers improves liquid stability of mRNA-LNPs

    doi: 10.64898/2026.03.05.709631

    Figure Lengend Snippet: Effect of apparent ionic strength of 50 mM pH 4 acidic mixing buffers on bleb formation of SM-102 LNPs.

    Article Snippet: Specifically, we investigated the effect of less common acidic buffers on mRNA-LNP stability using a LNP containing a clinically relevant ionizable lipid (SM-102) that is used by Moderna as a part of their respiratory vaccine platform LNP.

    Techniques: